Diagnostic Products

"To build long term customer relationships through value and excellent service."

Red blood cells rendered

I.W. Tremont has developed a complete line of lateral and vertical flow diagnostic grade materials with the efficacy of complete device in mind.  

Assembled as a cohesive design package as well as individual components that are equivalent to competitive grades, the offering includes these materials:

  • High yield whole blood separators
  • Dried Blood Spot paper
  • Absorbent pad
  • Conjugate pad
  • Wicking materials
  • Membranes
  • High resolution indicator paper
  • Base plane
  • Absorbent sinks



Material Specs

Grade Nomenclature Name Function Description
D-23® Whole Blood Separation Media

High efficacy and high quality plasma separator with  no red cell hemolysis

Borosillicate glass media 0.5mm thick, ready for application of your speicalized chemistries, plasma yield >15% by volume
D23®-TC1 Whole Blood Separation Media, Thin Caliper High efficacy and high quality plasma separator with  no red cell hemolysis, thin caliper has less holdup volume Borosillicate glass media with thin caliper, 0.375mm thick, ready for application of your speicalized chemistries, plasma yield >15% by volume
LF-D23®-X1 Whole Blood Separation Media. Lateral Flow, Nominal Hct Range Lateral flow plasma separator with  no red cell hemolysis Borosillicate glass media with lateral flow agglutinating chemistry, 0.5mm thick, plasma yield >40% by volume, nominal Hct
LF-D23®-X2 Whole Blood Separation Media. Lateral Flow, High Hct Range. Lateral flow plasma separator with  no red cell hemolysis Borosillicate glass media with lateral flow agglutinating chemistry, 0.5mm thick, plasma yield >40% by volume, high Hct
LF-D23®-TC1-X1 Whole Blood Separation Media. Lateral Flow, Nominal Hct Range. Thin Caliper Lateral flow plasma separator with  no red cell hemolysis and less holdup volume Borosillicate glass media with lateral flow agglutinating chemistry, thin caliper, 0.375mm thick, plasma yield >40% by volume, nominal Hct
LF-D23®-TC1-X2 Whole Blood Separation Media. Lateral Flow, HighHct Range. Thin Caliper Lateral flow plasma separator with  no red cell hemolysis and less holdup volume Borosillicate glass media with lateral flow agglutinating chemistry, thin caliper, 0.375mm thick, plasma yield >40% by volume, high Hct
CF-D23®-X1 Whole Blood Separation Media. Cross Flow, Nominal Hct Range Cross flow plasma separator with  no red cell hemolysis Borosillicate glass media with cross flow agglutinating chemistry, 0.5mm thick, plasma yield >40% by volume, nominal Hct
CF-D23®-TC1-X1 Whole Blood Separation Media. Cross Flow, Nominal Hct Range. Thin Caliper Cross flow plasma separator with  no red cell hemolysis and less holdup volume Borosillicate glass media with cross flow agglutinating chemistry, thin caliper, 0.375mm thick, plasma yield >40% by volume, nominal Hct
CA-1 Cellulose Acetate Fibrous Material Fluid well, prefilter, absorbent pad, cell scaffold, wick, collection media Non-woven material product platform which is highly modifiable in basis weight, density, porosity, surface treatments and other physical attributes
DBS 1.00 Binderless Borosilicate Glass Microfiber 0.65
WT2500hpc 1.20 Binderless Borosilicate Glass Microfiber 0.28
D 2.70 Binderless Borosilicate Glass Microfiber 0.60
E 1.50 Binderless Borosilicate Glass Microfiber 0.35

 

Products

Tremont lancet test in use

New Material Alert - July 2018 - Diagnostics Grade Cellulose Acetate Fibrous material.

Grade CA-1 is a non-woven material product platform which is highly modifiable in basis
weight, density, porosity, surface treatments and other physical attributes

Ideally suited as a

  • Bio-sample collection media
  • Wound care absorbent pad
  • Transdermal drug delivery media
  • Base material in a functionalized separation filter
  • Stand alone, chemical resistant, high loading filter
  • 3D cell scaffold in bioreactors or stirred cell devices
  • Component in bio-sensors
  • Lateral flow absorbent wick
  • High capacity fluidic well for POCT requiring chase buffers
  • Prefilter for higher retention CA surface membrane
  • Respiration & O2 therapy concentrator devices

Diagnostics Resource Booklet 

Inside you will find many specialty materials representing only a small portion of our available 150+ grade variants including

  • Wicking & Conjugate Pad applications
  • Rapid liquid sample mobilization
  • Whole blood separation applications
  • Cellulose Acetate material
  • Cellulose filter paper
    Dry Blood Spot Analysis
    High resolution indications
    Highly absorbent base grades
  • Blotter Grades and absorbent papers

Grade D-23® High Yield Whole Blood Separator Media

Red blood cells renderedThe Grade D-23® is a point of care diagnostics borosilicate glass microfiber filter media containing a proprietary acrylic binder system. This customizable material represents a platform of product variants. The base glass media is supplied ready for your application of chemistries. When supplied as a whole blood separator a novel coating technology is utilized which yields high quality plasma with surprising efficacy and no red cell Hemolysis . The coated version material has been developed by a CRO in the United States whose specialty is blood separation and device development. This market proven media is currently included as a component in successfully commercialized and patented devices with 510K filings.

This naturally hydrophilic material demonstrates high uniformity in formation and density allowing reliable migration rates, in both cross and lateral flow applications. With little caliper deviation the media is ideal for challenging lamination applications and micro fluidic devices.

Uniform screen & felt sides with consistent density MD/CD - This media demonstrates excellent lot-to-lot reproducibility - CofC and CofA provided with shipments – Manufactured in an FDA approved facility and available as rolls, reels, sheets and semi-finished converted configurations in both pre and post coated versions.

This media is available as a base glass microfiber which performs basic whole blood separation via precisely engineered porosity and fiber matrix. In this configuration the material demonstrates plasma yield of approximately 15% by volume at nominal Hct range. It is suitable for both lateral and cross flow configurations and is highly consistent in density and caliper for application of your own micro-coating and dip/dry saturation chemistry.

The D23® series of whole blood separating material is currently available in a total of 8 different iterations.   

Six versions of the blood separation media containing proprietary agglutinating chemistry coating are also available. In this coated version this material demonstrates plasma yield >40%.

The material in basic form (commonly referred to as “base glass”) separates the plasma strictly through precision filtration and capillary flow:

  • D23®  is the thickest, most robust glass microfiber (highest fluidic volume capacity)
  • D23-TC1® is a thinner, faster version of the glass microfiber (faster with lower dead volume)

 

Coated with high yield agglutinating process chemistry, LATERAL FLOW

  • LF-D23-X1 (thick version, designed for nominal Hct range, lateral flow)
  • LF-D23-X2 (thick version, designed for high Hct range, lateral flow)
  • LF-D23-TC1-X1 (thin version, designed for nominal Hct range, lateral flow)
  • LF-D23-TC1-X2 (thin version, designed for high Hct range, lateral flow)

 

Coated with high yield agglutinating process chemistry, CROSS FLOW

  • CF-D23-X1 (thick version, designed for nominal Hct range, cross flow vertical applications)
  • CF-D23-TC1-X1 (thin version, designed for nominal Hct range, cross flow vertical applications)

Dried Blood Spot Paper

High purity alpha cotton linter absorbent filter paper specifically formulated to yield a stable DNA, RNA and protein biomarker matrix for quantitative analysis. Surface texture, absorption rate and formation have been optimized for the Guthrie test. The formation is highly uniform and free from density irregularities.

Ideally suited as a specimen collection media for bioanalysis applications such as the collection of blood drops typical of the Guthrie test, a microbiological assay for the presence of phenylalanine, phenylpyruvate, and phenyllactate in blood or urine. Most notably the Guthrie test is used to screen newborn infants for phenylketonuria (PKU).

The purity and formation of the material offers a highly reproducible platform for direct elution techniques. Meets or exceeds results obtained using conventional manual extraction methodology in comparison to known competitive commercial equivalents. Paper punches cleanly demonstrating minimal extraneous fibers. Material holds embossing with or without heat set and converts well for incorporation into diagnostic devices.

Uniform screen & felt sides with consistent density MD/CD - Manufacturing performed with RO water filtration system - This media demonstrates excellent lot-to-lot reproducibility - Material chemistries are verified against a standard using GC techniques prior to paper making process - CofC and CofA provided with shipments – Available as rolls, reels, sheets and semi-finished converted configurations.

Basis Weight (g/m2): 180

Caliper Thickness (mm): 0.44 – 0.47

Migration Distance (mm/10 min): 120 - 135

Surface: Smooth, bright white

Known competitive grades*: GE Healthcare Whatman / S&S 903, Ahlstrom 226

*Use of competitive trademark or nomenclature for reference only. No ownership or license rights implied.

Grade WT2500hpc - High purity cellulose paper

Ideally suited as a high resolution indicator paper and specimen collection media for bioanalysis applications such as the collection of blood drops, urine or saliva. Efficient when used as a wick or absorbent pad under membrane for lateral flow or cross flow designs.

High purity alpha cotton linter absorbent filter paper specifically formulated to yield a stable DNA, RNA and protein biomarker matrix for quantitative analysis. The formation is highly uniform and free from density irregularities allowing fast indication and strong line hold.




Capabilities

IWTremont slitting operationIWTremont syringe filter assembly_1IWTremont clean room assembly processing

OEM and Custom Manufacturing

In addition to Tremont's significant standard production of analytical, laboratory and diagnostic products, we offer our services as your manufacturing partner.  

By utilizing a wide array of disciplines and resources we can modify an existing design or completely develop a new product or process. Cost efficiency is created with tight controls in timeline, budget, concurrent processes and production scale. We efficiently develop a viable early stage engineering plan to bring the project to your desired level of completion including short run, scale up and full commercialization.

Core capabilities:

• Wet lay processes for glass microfiber and cellulose media development
• Porous media development including modification of standard grades
• Hundreds of standard material grades in glass, cellulose and synthetics
• Converting such as slitting, die cutting, shearing, laminating & interleaving
• Component design for injection molding
• Component assembly using ultrasonic welding
• Inspection, insertion and encapsulation
• Device optimization and process consulting
• Short run to mid-volume manual operations
• Custom syringe and inline filter devices with integrity testing
• Kitting and special packaging
• ISO Class 8 & 9 clean room assembly and production

Partnered capabilities:

• Paper chemistry and pilot production
• Lateral flow device design and development
• Point of care device design
• Test strip production
• Micro gravure coating
• Rapid whole blood separation technologies
• Microfluidic device design



© 2018 1-IW Tremont - All Rights Reserved

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